Upside your head and down with polar bear opposite
2012: "The neutrinos are mutating!"
You have to love a disaster movie that doesn't just fly in the face of science, but pisses in the face of science too. The last minute or so of this video is toothache-inducingly stupid. (Sure, Doctor Who gave us "reverse the polarity of the neutron flow," but this is better. Or worse.) This line has become so famous, it has its own awesome T-shirt. Another great candidate from an Emmerich film: "I think we've hit a critical desalinization point," from Day After Tomorrow.